Question 1

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration.

Accepted Answer

A) True 
 B)False

Question 2

What gene(s) is/are encoded in the Xic?

Accepted Answer

A)   Xce
B)   Xist
C)   Tsix
D)   Both the Tsix and Xist are genes are in the Xic regionE) A) and B)
F) All of the above

Question 3

Genomic imprinting is a result of

Accepted Answer

A)   nucleosome location.
B)   histone activation.
C)   DNA methylation.
D)   serine to leucine changes in the genetic code.E) A) and B)
F) A) and C)

Question 4

How many Barr bodies would an individual with a XXY genotype possess?

Accepted Answer

A)   0
B)   1
C)   2
D)   None of the answers are correct.E) A) and B)
F) A) and C)

Question 5

Where is the IRE located in the ferritin gene?

Accepted Answer

A)   5′ end of DNA
B)   5′ end of mRNA
C)   3′ end of DNA
D)   3′ end of mRNAE) B) and D)
F) C) and D)

Question 6

A queen bee is larger than the female worker bees in a hive.The queen develops functional ovaries that allow her to produce up to 2000 eggs a day.What determines which bees become queen bees?

Accepted Answer

A)   A single dominant allele of the Queen gene
B)   The larvae raised on a diet of royal jelly
C)   The larvae raised on a diet of pollen and nectar
D)   The egg that hatches firstE) All of the above
F) B) and C)

Question 7

What gene is most responsible for X-chromosome inactivation?

Accepted Answer

A)   Xic
B)   Xist
C)   Tsix
D)   XceE) C) and D)
F) None of the above

Question 8

What is the molecular mechanism for imprinting a gene?

Accepted Answer

A)   Acetylation
B)   Nitration
C)   Phosphorylation
D)   MethylationE) B) and C)
F) A) and D)

Question 9

What general transcription factor is most often affected by regulatory transcription factors?

Accepted Answer

A)   TFIIB
B)   TFIID
C)   TFIIE
D)   TFIIFE) B) and C)
F) None of the above

Question 10

In imprinting of the Igf2 gene in mice,are the ICR and DMR methylated on the maternal or paternal chromosome? Which chromosome expresses Igf2?

Accepted Answer

A)   Paternal, paternal
B)   Paternal, maternal
C)   Maternal, paternal
D)   Maternal, maternalE) A) and B)
F) A) and C)

Question 11

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Accepted Answer

A) True 
 B)False

Question 12

Vernalization in Arabidopsis involves epigenetic changes as cold temperatures induce histone modifications that influence expression of genes for germination or flowering in the spring when temperatures increase.

Accepted Answer

A) True 
 B)False

Question 13

In the regulation of Igf2,it is possible that the effects of the association of the ICR and DMR regions with the CTC factors could be distance dependent. An experiment could be devised in which the distances between these regions could be varied and the rates of transcription could be measured. The graph shows some possible results. Which letter represents the most likely outcome if increasing the distance between ICR and DMR does not greatly enhance transcription until a critical distance is reached?

Accepted Answer

A)   A
B)   B
C)   C
D)   DE) All of the above
F) B) and C)

Question 14

What is a major difference between the general and regulatory transcription factors?

Accepted Answer

A)   General transcription factors only regulate the housekeeping genes while regulatory transcription factors control all of the other genes.
B)   General transcription factors are essential for any transcription for all genes while regulatory transcription factors regulate transcription of specific genes.
C)   General transcription factors act as heterodimers while regulatory transcription factors act as monomers.
D)   General transcription factors regulate basal genes while regulatory transcription factors control all of the other genes.E) C) and D)
F) A) and D)

Question 15

In cancer cells one allele of a tumor suppressor gene called p53 is frequently mutated so that the protein is inactive,not produced,or deleted. The other allele usually has a normal sequence and the promoter remains intact,but the gene is not expressed. Sequencing with sodium bisulfite modification of DNA can be used to detect which cytosines are methylated. If cancer cell DNA is sequenced,which of the following results would be expected?

Accepted Answer

A)   Cytosines in or near the promoter region will be methylated
B)   Cytosines in or near the promoter will not be methylated
C)   Cytosines in the coding region will have an increased methylation
D)   There will be no differences in the methylation pattern of the promoter of p53 from a cancer cell and a normal cellE) A) and C)
F) C) and D)

Question 16

Acetylation of histones results in

Accepted Answer

A)   formation of an open chromatin structure.
B)   removal of histones from the histone octomer.
C)   formation of a closed chromatin structure.
D)   termination of transcription.E) All of the above
F) None of the above

Question 17

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Accepted Answer

A)   TrxG proteins methylate lysine 27 on histone H3 while PcG complexes methylate lysine 4 on H3
B)   Methylation of lysine at position 4 on H3 results in silencing of gene expression
C)   TrxG complex proteins activate gene expression by methylating lysine 4 on H3, while PcG complex proteins repress gene expression by methylating lysine 27 on H3.
D)   Methylation of H3 on lysine 27 can result in activation of transcriptionE) B) and C)
F) A) and B)

Question 18

Which of the following is an example of epigenetic inheritance?

Accepted Answer

A)   Expression of the Igf2 gene based on methylation of the ICR and DMR regions
B)   Inheritance of flower color as studied by Mendel
C)   Control of mRNA stability by an RNA-binding protein
D)   Activation of transcription by a general transcription factorE) B) and D)
F) B) and C)

Question 19

Which of the following is part of the mechanism for epigenetic regulation of the Igf2 gene?

Accepted Answer

A)   Methylation of the H19 locus
B)   Methylation of the ICR and DMR domains
C)   Binding of CTC factors to methylated sequencesD) All of the above
E) None of the above

Question 20

Both parents usually imprint the same gene.

Accepted Answer

A) True 
 B)False

Exam 17: Gene Regulation in Eukaryotes

Where is the IRE located in the ferritin gene?

Correct Answer
verified

In imprinting of the Igf2 gene in mice,are the ICR and DMR methylated on the maternal or paternal chromosome? Which chromosome expresses Igf2?

Correct Answer
verified

Correct Answer
verified

A queen bee is larger than the female worker bees in a hive.The queen develops functional ovaries that allow her to produce up to 2000 eggs a day.What determines which bees become queen bees?

Correct Answer
verified

What general transcription factor is most often affected by regulatory transcription factors?

Correct Answer
verified

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration.

Correct Answer
verified

What gene(s) is/are encoded in the Xic?

Correct Answer
verified

What gene is most responsible for X-chromosome inactivation?

Correct Answer
verified

Acetylation of histones results in

Correct Answer
verified

Both parents usually imprint the same gene.

Correct Answer
verified

What is the molecular mechanism for imprinting a gene?

Correct Answer
verified

Which of the following is an example of epigenetic inheritance?

Correct Answer
verified

Which of the following is part of the mechanism for epigenetic regulation of the Igf2 gene?

Correct Answer
verified

Vernalization in Arabidopsis involves epigenetic changes as cold temperatures induce histone modifications that influence expression of genes for germination or flowering in the spring when temperatures increase.

Correct Answer
verified

What is a major difference between the general and regulatory transcription factors?

Correct Answer
verified

Genomic imprinting is a result of

Correct Answer
verified

How many Barr bodies would an individual with a XXY genotype possess?

Correct Answer
verified

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Correct Answer
verified

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Correct Answer
verified

Correct Answer
verified

Exam 17: Gene Regulation in Eukaryotes

Where is the IRE located in the ferritin gene?

Correct AnswerverifiedShow Answer

In imprinting of the Igf2 gene in mice,are the ICR and DMR methylated on the maternal or paternal chromosome? Which chromosome expresses Igf2?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

A queen bee is larger than the female worker bees in a hive.The queen develops functional ovaries that allow her to produce up to 2000 eggs a day.What determines which bees become queen bees?

Correct AnswerverifiedShow Answer

What general transcription factor is most often affected by regulatory transcription factors?

Correct AnswerverifiedShow Answer

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration.

Correct AnswerverifiedShow Answer

What gene(s) is/are encoded in the Xic?

Correct AnswerverifiedShow Answer

What gene is most responsible for X-chromosome inactivation?

Correct AnswerverifiedShow Answer

Acetylation of histones results in

Correct AnswerverifiedShow Answer

Both parents usually imprint the same gene.

Correct AnswerverifiedShow Answer

What is the molecular mechanism for imprinting a gene?

Correct AnswerverifiedShow Answer

Which of the following is an example of epigenetic inheritance?

Correct AnswerverifiedShow Answer

Which of the following is part of the mechanism for epigenetic regulation of the Igf2 gene?

Correct AnswerverifiedShow Answer

Vernalization in Arabidopsis involves epigenetic changes as cold temperatures induce histone modifications that influence expression of genes for germination or flowering in the spring when temperatures increase.

Correct AnswerverifiedShow Answer

What is a major difference between the general and regulatory transcription factors?

Correct AnswerverifiedShow Answer

Genomic imprinting is a result of

Correct AnswerverifiedShow Answer

How many Barr bodies would an individual with a XXY genotype possess?

Correct AnswerverifiedShow Answer

What is the difference between the trithorax (TrxG) and polycomb (PcG) complexes of proteins?

Correct AnswerverifiedShow Answer

Steroid hormones are an example of an effector which regulates regulatory transcription factor activity.

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified

Correct Answer
verified