Question 1

Kinases are enzymes that can phosphorylate (transfer phosphate groups onto)  macromolecules such as proteins. A particular kinase, Kinase 1 is known to promote cell division. It promotes cell division by phosphorylating Protein X. Phosphorylation of Protein X activates Protein X. Once activated, Protein X stimulates the production of other proteins such as Protein Y and Z that directly promote cell division. In order to function, Kinase 1 requires the presence of Metal A. However, in the presence of Protein A, Kinase 1 is nonfunctional. From the description, what is considered the substrate of Kinase 1?

Accepted Answer

A)   Protein Y
B)   Protein Z
C)   Metal A
D)   Protein X
E)   Protein AF) A) and E)
G) A) and D)

Question 2

Based on the graph below, what are the optimal temperatures for the human enzyme and the hotsprings prokaryote enzyme? oC; the optimal temperature for the hotsprings prokaryote enzyme is 79oC. B)  The optimal temperature for the human enzyme is 30oC; the optimal temperature for the hotsprings prokaryote enzyme is 60oC. C)  The optimal temperature for the human enzyme is 35oC; the optimal temperature for the hotsprings prokaryote enzyme is 65oC. D)  The optimal temperature for the human enzyme is 40oC; the optimal temperature for the hotsprings prokaryote enzyme is 72oC." class="answers-bank-image d-inline" rel="preload" >

Accepted Answer

A)   The optimal temperature for the human enzyme is 46oC; the optimal temperature for the hotsprings prokaryote enzyme is 79oC.
B)   The optimal temperature for the human enzyme is 30oC; the optimal temperature for the hotsprings prokaryote enzyme is 60oC.
C)   The optimal temperature for the human enzyme is 35oC; the optimal temperature for the hotsprings prokaryote enzyme is 65oC.
D)   The optimal temperature for the human enzyme is 40oC; the optimal temperature for the hotsprings prokaryote enzyme is 72oC.E) B) and C)
F) C) and D)

Question 3

Kinases are enzymes that can phosphorylate (transfer phosphate groups onto)  macromolecules such as proteins. A particular kinase, Kinase 1 is known to promote cell division. It promotes cell division by phosphorylating Protein X. Phosphorylation of Protein X activates Protein X. Once activated, Protein X stimulates the production of other proteins such as Protein Y and Z that directly promote cell division. In order to function, Kinase 1 requires the presence of Metal A. However, in the presence of Protein A, Kinase 1 is nonfunctional. From the description, what is considered a cofactor of Kinase 1?

Accepted Answer

A)   Protein A
B)   Protein X
C)   Protein Z
D)   Protein Y
E)   Metal AF) B) and D)
G) None of the above

Question 4

You eat a bowl of beans as part of your dinner. As you digest the beans, the proteins that are present get broken down to their component amino acids. As your body destroys the macromolecules that were present in the beans, is the energy present in those molecules destroyed?

Accepted Answer

A)   No. The energy contained within these macromolecules is converted into other forms of chemical energy and kinetic energy, though some is lost as heat.
B)   Yes. By breaking down these macromolecules, some of the energy they contained is destroyed.
C)   No. Breaking down molecules does not lead to the release of energy.
D)   No. While the vast majority of the energy contained in these macromolecules is converted to heat, it is not actually destroyed.E) C) and D)
F) A) and C) A

Question 5

Phosphofructokinase (PFK)  is an enzyme that converts fructose 6-phosphate to fructose 1,6-bisphosphate, by adding a phosphate group. This is the first committed step of the metabolic pathway of glycolysis, and thus it is very tightly regulated. AMP binds to PFK at a site distinct from the binding site for fructose 6-phosphate, and stimulates the formation of fructose 1,6-bisphosphate. ATP binds to PFK at a site distinct from the binding site for fructose 6-phosphate, and inhibits the formation of fructose 1,6-bisphosphate. There are other regulators of this enzyme as well. What is the role of AMP in this example?

Accepted Answer

A)   Competitive inhibitor
B)   Noncompetitive inhibitor
C)   Allosteric inhibitor
D)   Allosteric activator
E)   CatalystF) A) and E)
G) None of the above

Question 6

Carbonic anhydrase (CA) , an enzyme widely present in plant and animal tissues, catalyzes the reaction:
2 out of tissues; without a catalyst, this reaction would not occur at rates that could maintain homeostasis. In the figure below, which line(s)  represents the reaction catalyzed by carbonic anhydrase?   A)  Line B; the activation energy has been lowered. B)  Line A; the activation energy increased. C)  Lines A and B; product is shown for both lines. D)  Line A; more energy is supplied. E)  Either, as the free energy is the same for both." class="answers-bank-image d-inline" rel="preload" > This reaction is important for the maintenance of acid base balance in blood and other tissues and to help transport CO2 out of tissues; without a catalyst, this reaction would not occur at rates that could maintain homeostasis. In the figure below, which line(s)  represents the reaction catalyzed by carbonic anhydrase?
2 out of tissues; without a catalyst, this reaction would not occur at rates that could maintain homeostasis. In the figure below, which line(s)  represents the reaction catalyzed by carbonic anhydrase?   A)  Line B; the activation energy has been lowered. B)  Line A; the activation energy increased. C)  Lines A and B; product is shown for both lines. D)  Line A; more energy is supplied. E)  Either, as the free energy is the same for both." class="answers-bank-image d-inline" rel="preload" >

Accepted Answer

A)   Line B; the activation energy has been lowered.
B)   Line A; the activation energy increased.
C)   Lines A and B; product is shown for both lines.
D)   Line A; more energy is supplied.
E)   Either, as the free energy is the same for both.F) C) and D)
G) B) and D) A

Question 7

Why do we have storage macromolecules, such as fats, in our bodies?

Accepted Answer

A)   Macromolecules, such as fats, are a convenient way to store kinetic energy.
B)   Human cells can directly capture the energy of sunlight through photosynthesis and store it as macromolecules such as fats.
C)   Breaking down macromolecules, such as fats, is an endergonic process.
D)   We can break down these macromolecules to provide energy for the endergonic reactions in our bodies.E) All of the above
F) A) and C)

Question 8

A new antibiotic has been developed that inhibits the activity of an enzyme by competitive inhibition. What effect will this have on the activation energy of the enzyme-catalyzed reaction?

Accepted Answer

A)   The activation energy required for the reaction in the presence of the antibiotic would be less than the activation energy required in the absence of the antibiotic.
B)   The activation energy required for the reaction in the presence of the antibiotic will be the same as the activation energy required in the absence of the antibiotic.
C)   The activation energy required for the reaction in the presence of the antibiotic would be greater than the activation energy required in the absence of the antibiotic.D) B) and C)
E) All of the above

Question 9

The normal body temperature of a bat is similar to the normal body temperature of a human. Which of the curves below most likely represents an enzyme from a bat?

Accepted Answer

A)   C
B)   A
C)   BD) All of the above
E) B) and C)

Question 10

You are working with a specific enzyme-catalyzed reaction in the lab. You are a very careful experimentalist, and as a result, at the beginning of each of your experiments, you measure the temperature in the lab. On days 1 through 5, the temperature in the lab was 20oC. Today is day 6 of your experiment, and the temperature in the lab is 30oC. How do you predict that this will alter the rate of your enzyme-catalyzed reaction?

Accepted Answer

A)   It could possibly increase or decrease the rate.
B)   it will not affect the rate.
C)   It will increase the rate.
D)   It will decrease the rate.E) A) and D)
F) C) and D) A

Question 11

A current problem in modern medicine is the development of drug resistance mutations. This occurs when a mutation arises in a patient making him/her resistant to a drug and thus rendering the drug useless in treating a specific disease. Many useful drugs are competitive inhibitors of specific enzymes, and the drug-resistance mutations prevent the binding of the drug. These types of mutations, in addition to preventing competitive inhibitor binding, can also sometimes reduce the activity of the enzyme. Why is that the case?

Accepted Answer

A)   These mutations most likely affect an allosteric site on the enzyme
B)   These mutations lower the activation energy of the reaction catalyzed by the enzyme
C)   Binding to the competitive inhibitor is essential for the function of the enzyme
D)   These mutations most likely change the shape of the active site of the enzymeE) None of the above
F) A) and D)

Question 12

It is summer, and you are excited about going to your local amusement park, and specifically about riding the new roller coaster that was just built. You imagine waiting at the top of the stairs for the roller coaster to pull into the station, climbing into the car, strapping yourself into the seatbelt, and pulling down the harness. You can imagine the cars slowly chugging up to the top of the first hill, coming down on the other side, and the excitement you expect to feel as you go along for the ride. Of all of the things that you have imagined, which is an example of potential energy?

Accepted Answer

A)   Climbing into the car
B)   Waiting at the top of the stairs for the roller coaster to pull into the station
C)   The roller coaster car going up the first hill
D)   Pulling down the harnessE) B) and D)
F) All of the above

Question 13

Tacrolimus (FK-506)  is a drug that inhibits an enzyme called calcineurin. Calcineurin is a protein phosphatase. This is an enzyme that dephosphorylates (removes phosphate groups from)  proteins. When added to cells, tacrolimus can inhibit the dephosphorylation of a protein called NFAT, but it cannot prevent the dephosphorylation of a protein called CDK1. What is the most likely explanation for this finding?

Accepted Answer

A)   NFAT is a substrate of calcineurin, but CDK1 is not.
B)   Tacrolimus changes the optimum pH for calcineurin.
C)   Tacrolimus is a competitive inhibitor of calcineurin for NFAT, but not for CDK1.
D)   Calcineurin requires an additional cofactor to dephosphorylate NFAT.E) None of the above
F) A) and B)

Question 14

Glucose is broken down through cellular respiration, which involves a large number of chemical reactions. At the end of the cellular respiration process, a large number of ATP molecules are generated, yet not all of the possible energy that is contained in a molecule of glucose can be harnessed through these chemical reactions to generate ATP. In other words, during cellular respiration, not all of the energy that is contained in a molecule of glucose is converted into the energy stored in ATP. The remaining energy is

Accepted Answer

A)   lost as heat.
B)   donated to molecules in the cellular respiration process to reduce them.
C)   destroyed.
D)   used to drive exergonic reactions.E) C) and D)
F) All of the above

Question 15

AMP-activated protein kinase (AMPK)  is an enzyme that is activated by high levels of AMP in cells. If levels of AMP are high in cells, that means that levels of ATP are low. Once active, AMPK activates catabolic pathways and inhibits anabolic pathways in the cell. Why do you think that is the case? Choose the answer that best explains the role of AMPK.

Accepted Answer

A)   High levels of AMP indicate that there is a high amount of energy stored in the cell, thus activating catabolic pathways and inhibiting anabolic pathways are mechanisms to use stored energy.
B)   By activating catabolic pathways, AMPK provides a mechanism to activate exergonic pathways, which is important if AMP levels are high in the cell.
C)   Activating catabolic pathways and inhibiting anabolic pathways will ultimately lead to higher consumption of ATP, which is important if AMP levels are high in the cell.
D)   By inhibiting anabolic pathways, AMPK provides a mechanism to generate heat for the cell, which is important if AMP levels are high in the cell.E) A) and D)
F) C) and D)

Question 16

In an experiment described in a chemistry lab book, the directions state that after mixing two chemicals (A and B)  and waiting 5 minutes that A will be oxidized. This means that

Accepted Answer

A)   chemical A has gained energy in the form of heat from chemical B.
B)   chemical A has gained electrons from chemical B.
C)   chemical A has reacted with oxygen.
D)   chemical A has lost energy in the form of heat to chemical B.
E)   chemical A has lost electrons to chemical B.F) B) and D)
G) None of the above

Question 17

Many metabolic pathways are ultimately concerned with ATP; either with the generation of ATP, or with the requirement of ATP for that pathway to function. Why is ATP so important to metabolism?

Accepted Answer

A)   ATP is a protein that serves as the energy currency of cells.
B)   The phosphate groups of ATP are held together by unstable bonds that can be broken to release energy.
C)   Hydrolysis of the bond between adenine and ribose in ATP is commonly used to release energy that can be used to drive other cellular reactions.
D)   Hydrolysis of ATP is used to drive exergonic reactions.E) A) and C)
F) B) and C)

Exam 6: Energy and Metabolism

Correct Answer
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Based on the graph below, what are the optimal temperatures for the human enzyme and the hotsprings prokaryote enzyme?

Correct Answer
verified

Correct Answer
verified

You eat a bowl of beans as part of your dinner. As you digest the beans, the proteins that are present get broken down to their component amino acids. As your body destroys the macromolecules that were present in the beans, is the energy present in those molecules destroyed?

Correct Answer
verified
A

Correct Answer
verified

Correct Answer
verified
A

Why do we have storage macromolecules, such as fats, in our bodies?

Correct Answer
verified

A new antibiotic has been developed that inhibits the activity of an enzyme by competitive inhibition. What effect will this have on the activation energy of the enzyme-catalyzed reaction?

Correct Answer
verified

The normal body temperature of a bat is similar to the normal body temperature of a human. Which of the curves below most likely represents an enzyme from a bat?

Correct Answer
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A

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Correct Answer
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In an experiment described in a chemistry lab book, the directions state that after mixing two chemicals (A and B) and waiting 5 minutes that A will be oxidized. This means that

Correct Answer
verified

Many metabolic pathways are ultimately concerned with ATP; either with the generation of ATP, or with the requirement of ATP for that pathway to function. Why is ATP so important to metabolism?

Correct Answer
verified

Exam 6: Energy and Metabolism

Correct AnswerverifiedShow Answer

Based on the graph below, what are the optimal temperatures for the human enzyme and the hotsprings prokaryote enzyme?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

You eat a bowl of beans as part of your dinner. As you digest the beans, the proteins that are present get broken down to their component amino acids. As your body destroys the macromolecules that were present in the beans, is the energy present in those molecules destroyed?

Correct AnswerverifiedA

Correct AnswerverifiedShow Answer

Correct AnswerverifiedA

Why do we have storage macromolecules, such as fats, in our bodies?

Correct AnswerverifiedShow Answer

A new antibiotic has been developed that inhibits the activity of an enzyme by competitive inhibition. What effect will this have on the activation energy of the enzyme-catalyzed reaction?

Correct AnswerverifiedShow Answer

The normal body temperature of a bat is similar to the normal body temperature of a human. Which of the curves below most likely represents an enzyme from a bat?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedA

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

In an experiment described in a chemistry lab book, the directions state that after mixing two chemicals (A and B) and waiting 5 minutes that A will be oxidized. This means that

Correct AnswerverifiedShow Answer

Many metabolic pathways are ultimately concerned with ATP; either with the generation of ATP, or with the requirement of ATP for that pathway to function. Why is ATP so important to metabolism?

Correct AnswerverifiedShow Answer

Correct Answer
verified

Correct Answer
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A

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A

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A

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