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Genome studies show us that many genes and gene families are highly


A) active.
B) variable.
C) conserved.
D) associational.
E) endogenous.

F) B) and D)
G) C) and D)

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Genes with the same ancestral sequence are known as ___________________.

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orthologues

Which one of the following statements about the evolution of speech is false?


A) In humans a single point mutation in the FOXP2 gene impairs speech and grammar.
B) FOXP2 may be involved in songbird singing and mouse vocalization.
C) The protein coded by the FOXP2 gene differs by only two amino acids in humans and chimps.
D) The FOXP2 gene is involved in the control of the neuromuscular pathway leading to complex sound formation.
E) FOXP2 codes for a hormone that directly targets the muscles of the larynx and mouth.

F) B) and D)
G) All of the above

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The genomes of Arabidopsis thaliana,a small member of the mustard family of plants,and rice,Oryza sativa,have been sequenced.The findings include


A) the genome for each is almost identical,indicating that they diverged in the fairly recent past.
B) they each have very high copy numbers (slightly divergent copies of a gene) ,probably indicating episodes of polyploidy and/or segmental duplication.
C) repetitive DNA,including retrotransposons,was a very small proportion of both genomes.
D) more than 90% of the genes in each were particular to plants and not found in animal or fungal genomes.

E) A) and C)
F) B) and C)

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Which one of the following statements about foreign DNA in the human genome is false?


A) Most of the foreign DNA in the human genome is ancient.
B) Most of the foreign DNA in the human genome exists as transposons.
C) Like the Drosophila genome,the human genome is constantly eliminating its foreign DNA.
D) Little new foreign DNA is entering the human genome.

E) B) and C)
F) All of the above

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Which one of the following statements about the role of genome analysis in crop improvement is false?


A) Conservation of synteny will hinder our ability to find agriculturally important genes in plants.
B) Arabidopsis has no commercial significance except as a model organism.
C) Sequencing of the rice genome was important because it is related to many other cereal crop plants.
D) Sequencing the genomes of beneficial microbes has already begun.
E) Insertion of genes from beneficial microbes into plant genomes can be used to improve crop yields.

F) A) and C)
G) C) and D)

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Genes that have DNA sequences similar to functional genes but that do not appear to produce any functional product are _________________.

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Regarding the differences between the human genome and the tiger pufferfish genome


A) little can be said since pufferfish are not vertebrates-they are too different to compare.
B) essentially all the human genes have nearly identical counterparts in pufferfish.
C) the order of genes along the chromosomes in both species is essentially identical.
D) both species have about the same amount of introns and "nonsense" sequences of DNA.
E) about 25% of the human genes are unique when compared to the tiger pufferfish.

F) C) and D)
G) None of the above

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Which one of the following statements about the genomes of plants (especially Arabidopsis and rice) ,animals,and fungi is false?


A) Plants,animals,and fungi share most of the same genes for intermediary metabolism,genome replication,and protein synthesis.
B) "Plant" genes include those coding for photosynthetic pathways and morphology.
C) Plants generally have larger genomes than animals and fungi.
D) Rice has fewer genes than humans.
E) About 80% of the genomes of Arabidopsis and rice are the samE.

F) C) and D)
G) A) and B)

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D

The human genome


A) has no foreign DNA,it is excised by DNAases when it occurs.
B) has a very small amount of foreign DNA,mostly in the end caps (telomeres) of chromosomes.
C) has a lot of foreign DNA,mostly in the end caps (telomeres) of chromosomes.
D) has a lot of foreign DNA scattered throughout the genome,including transposons.
E) has entire foreign genes that are generally activated but produce harmless proteins.

F) B) and E)
G) B) and D)

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One of the reasons that pufferfish are a good species to compare to humans is because


A) it is so easy to hybridize the two and investigate the consequences.
B) they are so distantly related that it's easy to distinguish mutually conserved sequences.
C) the introns are often identical.
D) of the rapid response time in pufferfish to artificial selection.
E) they have been separated for so many millions of years and yet the gene sequence is almost identical.

F) A) and C)
G) All of the above

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B

Which one of the following statements about horizontal gene transfer is false?


A) Horizontal gene transfer is also called lateral gene transfer.
B) Horizontal gene transfer involves hitchhiking genes from other species.
C) Horizontal gene transfer was common early in life,but is absent today.
D) Gene swapping is evident in the human genome.
E) The products of horizontal gene transfer often exist as transposons.

F) C) and E)
G) A) and E)

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The types of human genes least likely to be duplicated,resulting in multiple copies,are


A) growth and development genes.
B) immune system genes.
C) genes for cell surface receptors.
D) genes controlling basic metabolism.

E) A) and B)
F) A) and C)

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Genes are assumed to be passed from generation to generation.This process is called _________________ gene transfer.

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Some of the olfactory receptor (OR) genes in humans


A) have mutated dramatically away from the same genes in other primates.
B) have been inactivated,reducing our olfactory capabilities compared to other primates.
C) have been activated,enhancing our olfactory sense compared to other primates.
D) have duplicated more frequently,resulting in increased paralogs compared to other primates.
E) have been conserved more rigidly,resulting in increased orthologs compared to other primates.

F) A) and B)
G) All of the above

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Which of the following statements about orthologues and paralogues is false?


A) Orthologues are likely to have the same function.
B) Both orthologues and paralogues result from gene duplication.
C) The sequence of an orthologue is more likely to be conserved.
D) Paralogues are more likely to be pseudogenes than orthologues.
E) Paralogues often evolve new functions.

F) B) and D)
G) C) and E)

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Which one of the following shows the correct sequence of events involving allopolyploidy that gave rise to modern tobacco?


A) hybridization,chromosome doubling,duplicate gene loss
B) hybridization,duplicate gene loss,chromosome doubling
C) chromosome doubling,hybridization duplicate gene loss
D) duplicate gene loss,hybridization,chromosome doubling

E) A) and B)
F) All of the above

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Over long segments of chromosomes,the linear order of mouse and human genes is the same.This is called conservation of _______________.

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Duplication of individual chromosomes instead of whole genomes can occur by _________________.

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Which one of the following statements describing what we know about Plasmodium falciparum,the parasitic protist that causes malaria,is false?


A) P.falciparum has many genes with similar function clustered together on its chromosomes.
B) P.falciparum is difficult for the immune system to target because it "cloaks" itself inside of red blood cells.
C) P.falciparum has inherited a unique subcellular organelle called an apicoplast from the chloroplast of an alga.
D) Although the P.falciparum apicoplast has no known function,targeting the apicoplast with chloroplast-specific herbicides might kill the parasite.

E) C) and D)
F) All of the above

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