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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. A 12-year-old male is admitted to the pediatric unit due to persistent upper respiratory symptoms and respiratory distress. The patient has a history of developmental delay, chronic lung disease, and frequent respiratory infections. Upon assessment, as the RN, you note the patient to have a fever, moderate respiratory rate, productive cough, and large amount of nasal secretions. Upon report from the patient’s mother, the patient has been on a 3-week course of antibiotics with no improvement in symptoms. Upon further workup, the patient is diagnosed with bacterial pneumonia and methicillin-resistant Staphylococcus aureus (MRSA) superinfection. -The use of which of the following drugs results in the highest risk of superinfection in a treated patient?


A) broad-spectrum antibiotics
B) narrow-spectrum antibiotics
C) topical antibiotics
D) antivirals

E) None of the above
F) B) and D)

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The MIC is the smallest concentration of an antimicrobial required to inhibit the growth of the microbe.

A) True
B) False

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Drugs that are hepatotoxic cause damage to a patient's kidneys.

A) True
B) False

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Which of the following block HIV binding to host cell receptors?


A) AZT
B) acyclovir
C) nevirapine
D) fuzeon
E) amantidine

F) D) and E)
G) B) and E)

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Antibiotics are derived from all of the following except


A) Penicillium.
B) Bacillus.
C) Staphylococcus.
D) Streptomyces.
E) Cephalosporium.

F) B) and D)
G) B) and C)

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The use of a drug to prevent a person at risk of an imminent infection is called


A) competitive inhibition.
B) synergism.
C) prebiotics.
D) prophylaxis.
E) lantibiotics.

F) A) and B)
G) None of the above

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When a patient's immune system reacts adversely to a drug,this serious side effect is called a superinfection.

A) True
B) False

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. A 12-year-old male is admitted to the pediatric unit due to persistent upper respiratory symptoms and respiratory distress. The patient has a history of developmental delay, chronic lung disease, and frequent respiratory infections. Upon assessment, as the RN, you note the patient to have a fever, moderate respiratory rate, productive cough, and large amount of nasal secretions. Upon report from the patient’s mother, the patient has been on a 3-week course of antibiotics with no improvement in symptoms. Upon further workup, the patient is diagnosed with bacterial pneumonia and methicillin-resistant Staphylococcus aureus (MRSA) superinfection. -Treatment of urinary tract infections often leads to a superinfection caused by which microbe?


A) Giardia lamblia
B) Lactobacillus acidophilus
C) Escherichia coli
D) Candida albicans

E) A) and B)
F) A) and C)

Correct Answer

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Side effects that occur in patient's tissues while on antimicrobial drugs include all the following except


A) development of resistance to the drug.
B) hepatotoxicity.
C) nephrotoxicity.
D) diarrhea.
E) deafness.

F) A) and C)
G) B) and D)

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The _____ are drugs that deposit in developing teeth and cause a permanent brown discoloration.


A) streptomycins
B) cephalosporins
C) macrolides
D) tetracyclines
E) penicillins

F) C) and D)
G) B) and C)

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Acyclovir is used to treat


A) influenza A virus.
B) HIV.
C) herpes simplex virus.
D) respiratory syncytial virus.
E) hepatitis C virus.

F) C) and E)
G) All of the above

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Each of the following contributes to emerging drug resistance except


A) overuse of antibiotics.
B) improper use of antibiotics.
C) multiple drug therapy.
D) ingestion of antibiotics with animal feed.
E) addition of antibiotics to common household products.

F) A) and E)
G) B) and E)

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Primaquine and chloroquine are drugs used in the treatment of


A) gram-positive infections.
B) gram-negative infections.
C) fungal infections.
D) protozoan infections.
E) viral infections.

F) C) and E)
G) D) and E)

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A ratio of the dose of a drug that is toxic to humans versus the minimum effective dose for that pathogen is assessed to predict the potential for toxic drug reactions.This is called the


A) Kirby-Bauer.
B) antibiogram.
C) E-test.
D) MIC.
E) therapeutic index (TI) .

F) A) and E)
G) None of the above

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. A 76-year-old male visits his primary care physician with complaints of burning with urination and a frequent urge to void. As the RN, you aid the patient in collecting a urine specimen to be sent for analysis. While awaiting the final results of drug susceptibility testing in the lab, the patient is prescribed oral sulfasoxazole. -The in vivo susceptibility of the pathogen is established,and the patient is maintained on sulfasoxazole.If no in vivo effect of the drug is observed by the patient following the first 7 days of antibiotics,what is the most appropriate action by the medical team?


A) increase the dose of sulfasoxazole
B) discontinue antibiotic therapy
C) discontinue sulfasoxazole and initiate a new antibiotic
D) initiate antiviral therapy

E) All of the above
F) A) and D)

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. As an RN in a medical intensive care unit, you are participating in a research study regarding administration of probiotics to critically ill patients receiving antibiotic therapy. You provide education as part of the consent process to patients, families, and other staff members. -Which of the following is an example of a probiotic?


A) penicillin
B) micafungin
C) yogurt
D) fructans

E) B) and C)
F) A) and C)

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It is better to use a broad-spectrum drug instead of a more specific narrow-spectrum drug.

A) True
B) False

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Each of the following result in drug resistance except


A) drug pumped out of the cell.
B) drug used as a nutrient by the cell.
C) drug binding site altered.
D) drug inactivated.
E) drug blocked from entering cell.

F) A) and B)
G) D) and E)

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. As an RN in a medical intensive care unit, you are participating in a research study regarding administration of probiotics to critically ill patients receiving antibiotic therapy. You provide education as part of the consent process to patients, families, and other staff members. -You indicate to the patient that research has demonstrated that probiotics may also be useful in the management of allergies caused by


A) animal dander.
B) pollen.
C) food.
D) detergents.

E) All of the above
F) A) and B)

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Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format. As an RN in a medical intensive care unit, you are participating in a research study regarding administration of probiotics to critically ill patients receiving antibiotic therapy. You provide education as part of the consent process to patients, families, and other staff members. -Following the teaching to patients and families,you assess understanding of the teaching prior to obtaining consent.All of the following are accurate statements by a patient regarding probiotics,except probiotics


A) are live microorganisms.
B) are nutrients to encourage microbe growth.
C) augment the microbes in the intestine.
D) can replace microbes killed during antibiotic therapy.

E) A) and D)
F) B) and C)

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